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Shereece Singleton
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Peer-Reviewed Publications
- Yang H, Smith RD, Chandler CE, Johnson J, Jackson SN, Woods AS, Scott AJ, Goodlett DR, and Ernst RK (2022) Lipid A structural determination from a single colony. Analytic Chemistry. Accepted for publication 5/3/2022
- Wong Fok Lung T, Charytonowicz D, Beaumont KG, Shah SS, Sridhar SH, Gorrie CL, Mu A, Hofstaedter CE, Varisco D, McConville TH, Drikic M, Fowler B, Urso A, Shi W, Fucich D, Annavajhala MK, Khan IN, Oussenko I, Francoeur N, Smith ML, Stockwell BR, Lewis IA, Hachani A, Upadhyay Baskota S, Uhlemann AC, Ahn D, Ernst RK, Howden BP, Sebra R, and Prince A (2022) Klebsiella pneumoniae induces host metabolic stress that promotes tolerance to pulmonary infection. Cell Metab. S1550-4131(22)00097-3.PMID: 35413274
- Postolache TT, Upadhyaya SK, Spector AM, Mohyuddin I, Constantine N, Ernst RK, Wadhawan A, Dutra SVO, Dagdag A, Makkar H, Lowry CA, Akram F, Fuchs D, Brenner LA, Groer MW, and Reynolds MA.(2022) Decreasing Tryptophan and Increasing Neopterin Plasma Levels During Pregnancy are Associated with High First Trimester Porphyromonas gingivalis K-Serotype IgG Serointensity in a cohort of Hispanic Women. Curr Top Med Chem. 2022 Apr 4.PMID: 35379151
- Bray AS, Smith RD, Hudson AW, Hernandez GE, Young TM, George HE, Ernst RK, and Zafar MA. (2022) MgrB-Dependent Colistin Resistance in Klebsiella pneumoniae Is Associated with an Increase in Host-to-Host Transmission. mBio. 13(2):e0359521. PMID: 35311534
- Wong TY, Lee KS, Russ BP, Horspool AM, Kang J, Winters MT, Allison Wolf M, Rader NA, Miller OA, Shiflett M, Izac J, Varisco D, Sen-Kilic E, Cunningham C, Cooper M, Cyphert HA, Barbier M, Martinez I, Bevere JR, Ernst RK, and Damron FH. (2022) Intranasal administration of BReC-CoV-2 COVID-19 vaccine protects K18-hACE2 mice against lethal SARS-CoV-2 challenge. NPJ Vaccines. 7(1):36. PMID: 35288576
- Gerster T, Wröbel M, Hofstaedter CE, Schwudke D, Ernst RK, Ranf S, and Gisch N (2022) Remodeling of Lipid A in Pseudomonas syringae pv. phaseolicola In Vitro .Int J Mol Sci. 23(4):1996. PMID: 35216122
- Smith RD, McElheny CL, Izac JR, Gardner FM, Chandler CE, Goodlett DR, Doi Y, Johnson JK, and Ernst RK. (2022) A Novel Lipid-Based MALDI-TOF Assay for the Rapid Detection of Colistin-Resistant Enterobacter Species. Microbiol Spectr. Feb 2;10(1):e0144521. PMID: 35107363
- Smith RD, Izac JR, Ha M, Yang H, Johnson JK, and Ernst RK. (2021) Rapid identification of mcr-1-positive Escherichia coli from patient urine using a novel lipid-based MALDI-TOF-MS assay. Access Microbiol. 2021 Dec 17;3(12):000309. PMID: 35024564
- Yeung WY, Tordik PA, Martinho FC, and Ernst RK. (2021) Positively Charged Polyvinylidene Fluoride Membrane: A Potential Alternative for Absorbent Paper Points in Endodontics. J Endod. 2021 Nov 20:S0099-2399(21)00801-3.: 34813795
- Nanishi E, Borriello F, O'Meara TR, McGrath ME, Saito Y, Haupt RE, Seo HS, van Haren SD, Cavazzoni CB, Brook B, Barman S, Chen J, Diray-Arce J, Doss-Gollin S, De Leon M, Prevost-Reilly A, Chew K, Menon M, Song K, Xu AZ, Caradonna TM, Feldman J, Hauser BM, Schmidt AG, Sherman AC, Baden LR, Ernst RK, Dillen C, Weston SM, Johnson RM, Hammond HL, Mayer R, Burke A, Bottazzi ME, Hotez PJ, Strych U, Chang A, Yu J, Sage PT, Barouch DH, Dhe-Paganon S, Zanoni I, Ozonoff A, Frieman MB, Levy O, and Dowling DJ. (2021) An aluminum hydroxide:CpG adjuvant enhances protection elicited by a SARS-CoV-2 receptor-binding domain vaccine in aged mice. .Sci Transl Med. 2021 Nov 16:eabj5305. PMID: 34783582
- Li H, Mattingly AE, Jania LA, Smith R, Melander RJ, Ernst RK, Koller BH, and Melander C (2021) Benzimidazole Isosteres of Salicylanilides Are Highly Active Colistin Adjuvants. ACS Infect Dis. 2021 Dec 10;7(12):3303-3313.PMID: 34752055
- Howlander DR, Das S, Lu T, Hu G, Varisco DJ, Dietz ZK, Walton SP, Ratnakaram SSK, Gardner FM, Ernst RK, Picking WD, and Picking WL (2021) Effect of Two Unique Nanoparticle Formulations on the Efficacy of a Broadly Protective Vaccine Against Pseudomonas aeruginosa. Front. Pharmacol., 18 August. doi: 10.3389/fphar.2021.706157
- Haupt RE, Harberts EM, Kitz RJ, Strohmeier S, Krammer F, Ernst RK, Frieman MB (2021) Novel TLR4 adjuvant elicits protection against homologous and heterologous Influenza A infection. Vaccine, Accepted for publication 7/21.
- Gauthier AE, Chandler CE, Poli V, Gardner FM, Tekiau A, Smith R, Bonham KS, Cordes EE, Shank TM, Zanoni I, Goodlett DR, Biller SJ, Ernst RK, Rotjan RD, Kagan JC (2021) Deep-sea microbes as tools to refine the rules of innate immune pattern recognition. Science Immunol. 12;6(57):eabe0531. PMID: 33712473
- Ernst O, Khan MM, Oyler BL, Yoon SH, Sun J, Lin FY, Manes NP, MacKerell AD Jr, Fraser IDC, Ernst RK, Goodlett DR, Nita-Lazar A (2021) Species-Specific Endotoxin Stimulus Determines Toll-Like Receptor 4- and Caspase 11-Mediated Pathway Activation Characteristics. mSystems. Aug 3:e0030621. PMID: 34342534
- Adamiak JW, Jhawar V, Bonifay V, Chandler CE, Leus IV, Ernst RK, Schweizer HP, Zgurskaya HI. (2021) Loss of RND-type multidrug efflux pumps triggers iron starvation and lipid A modifications in Pseudomonas aeruginosa. Antimicrob Agents Chemother. Jul 12:AAC0059221. PMID: 34252310
- Chattagul S, Khan MM, Scott AJ, Nita-Lazar A, Ernst RK, Goodlett DR, Sermswan RW. (2021) Transcriptomics Analysis Uncovers Transient Ceftazidime Tolerance in Burkholderia Biofilms. ACS Infect Dis. 7(8):2324-2336. PMID: 34138549
- Ahn D, Bhushan G, McConville TH, Annavajhala MK, Soni RK, Wong Fok Lung T, Hofstaedter CE, Shah SS, Chong AM, Castano VG, Ernst RK, Uhlemann AC, Prince A (2021) An acquired acyltransferase promotes Klebsiella pneumoniae ST258 respiratory infection. Cell Rep. 35(9):109196. PMID: 34077733
- Nanishi E, Borriello F, O'Meara TR, McGrath ME, Saito Y, Haupt RE, Seo HS, van Haren SD, Brook B, Chen J, Diray-Arce J, Doss-Gollin S, Leon M, Chew K, Menon M, Song K, Xu AZ, Caradonna TM, Feldman J, Hauser BM, Schmidt AG, Sherman AC, Baden LR, Ernst RK, Dillen C, Weston SM, Johnson RM, Hammond HL, Mayer R, Burke A, Bottazzi ME, Hotez PJ, Strych U, Chang A, Yu J, Barouch DH, Dhe-Paganon S, Zanoni I, Ozonoff A, Frieman MB, Levy O, Dowling DJ (2021) Alum:CpG adjuvant enables SARS-CoV-2 RBD-induced protection in aged mice and synergistic activation of human elder type 1 immunity. bioRxiv. May 21:2021.05.20.444848. PMID: 34031655
- Guillotte ML, Chandler CE, Verhoeve VI, Gillespie JJ, Driscoll TP, Rahman MS, Ernst RK, Azad AF (2021) Lipid A Structural Divergence in Rickettsia Pathogens. mSphere. 6(3):e00184-21. PMID: 33952661
- Cross AS, Opal SM, Palardy JE, Shridhar S, Baliban SM, Scott AJ, Chahin AB, Ernst RK. (2021) A pilot study of an anti-endotoxin Ig-enriched bovine colostrum to prevent experimental sepsis. Innate Immun. 27(3):266-274. PMID: 33858243
- Band VI, Satola SW, Smith RD, Hufnagel DA, Bower C, Conley AB, Rishishwar L, Dale SE, Hardy DJ, Vargas RL, Dumyati G, Kainer MA, Phipps EC, Pierce R, Wilson LE, Sorensen M, Nilsson E, Jordan IK, Burd EM, Farley MM, Jacob JT, Ernst RK, Weiss DS (2021) Colistin Heteroresistance Is Largely Undetected among Carbapenem-Resistant Enterobacterales in the United States. mBio. Jan 26;12(1):e02881-20. PMID: 33500343
- Cetuk H, Anishkin A, Scott AJ, Rempe SB, Ernst RK, Sukharev S. (2021) Partitioning of Seven Different Classes of Antibiotics into LPS Monolayers Supports Three Different Permeation Mechanisms through the Outer Bacterial Membrane. Feb 2;37(4):1372-1385. Epub 2021 Jan 15.PMID: 33449700
- Zacharia A, Harberts E, Valencia SM, Myers B, Sanders C, Jain A, Larson NR, Middaugh CR, Picking WD, Difilippantonio S, Kirnbauer R, Roden RB, Pinto LA, Shoemaker RH, Ernst RK, Marshall JD. (2020) Optimization of RG1-VLP vaccine performance in mice with novel TLR4 agonists. Vaccine. Dec 10:S0264-410X(20)31541-3. Online ahead of print. PMID: 33309485
- Sorensen M, Chandler CE, Gardner FM, Ramadan S, Khot PD, Leung LM, Farrance CE, Goodlett DR, Ernst RK, Nilsson E. (2020) Rapid microbial identification and colistin resistance detection via MALDI-TOF MS using a novel on-target extraction of membrane lipids. Sci Rep. 2020 Dec 9;10(1):21536. PMID: 33299017. * Co-senior Author
- Wolter DJ, Scott A, Armbruster CR, Whittington D, Edgar JS, Qin X, Buccat AM, McNamara S, Blackledge M, Waalkes A, Salipante SJ, Ernst RK, Hoffman LR. (2020) Repeated isolation of an antibiotic-dependent and temperature-sensitive mutant of Pseudomonas aeruginosa from a cystic fibrosis patient. J Antimicrob Chemother. Dec 1:dkaa482. Online ahead of print. PMID: 33259594
- Nelson N, Opene B, Ernst RK, Schwartz DK. (2020) Antimicrobial peptide activity is anticorrelated with lipid A leaflet affinity. PLoS One. 2020 Nov 30 eCollection. PMID: 33253275
- Yang H, Jackson SN, Woods AS, Goodlett DR, Ernst RK, Scott AJ (2020) Streamlined Analysis of Cardiolipins in Prokaryotic and Eukaryotic Samples Using Norharmane Matrix by MALDI-MSI. J Am Soc Mass Spectrom. Sep 14. doi: 10.1021/jasms.0c00201. Online ahead of print. PMID: 32924474
- Mattingly AE, Cox KE, Smith R, Melander RJ, Ernst RK, Melander C (2020) Screening an Established Natural Product Library Identifies Secondary Metabolites That Potentiate Conventional Antibiotics. ACS Infect Dis. Sep 11. doi: 10.1021/acsinfecdis.0c00259. Online ahead of print. PMID: 32810395
- Yang H, Chandler CE, Jackson SN, Woods AS, Goodlett DR, Ernst RK, Scott AJ (2020) On-tissue derivatization of lipopolysaccharide for detection of lipid A using MALDI-MSI. Anal Chem. 2020 Sep 9. doi: 10.1021/acs.analchem.0c02566. Online ahead of print. PMID: 32902263
- Chandler CE, Harberts EM, Pelletier MR, Thaipisuttikul I, Jones JW, Hajjar AM, Sahl JW, Goodlett DR, Pride AC, Rasko DA, Trent MS, Bishop RE, Ernst RK. (2020) Early evolutionary loss of the lipid A modifying enzyme PagP resulting in innate immune evasion in Yersinia pestis. Proc Natl Acad Sci USA. doi: 10.1073/pnas.1917504117. Online ahead of print. PMID: 32868431
- Leus IV, Adamiak J, Trinh AN, Smith RD, Smith L, Richardson S, Ernst RK, Zgurskaya HI. (2020) Inactivation of AdeABC and AdeIJK efflux pumps elicits specific nonoverlapping transcriptional and phenotypic responses in Acinetobacter baumannii. Mol Microbiol. doi: 10.1111/mmi.14594. Online ahead of print. PMID: 32858760
- Brao KJ, Wille BP, Lieberman J, Ernst RK, Shirtliff ME, Harro JM. (2020) Scnn1b-transgenic BALB/c mice as a model of Pseudomonas aeruginosa infections of the cystic fibrosis lung. Infect Immun. Jul 6:IAI.00237-20. doi: 10.1128/IAI.00237-20. PMID: 32631918
- Ryu SY, Wendt GA, Ernst RK, Goodlett DR. (2020) MGMS2: Membrane Glycolipid Mass Spectrum Simulator for polymicrobial samples. Rapid Commun Mass Spectrom. May 8:e8824. doi: 10.1002/rcm.8824. PMID: 32384576
- Richard K, Perkins DJ, Harberts EM, Song Y, Gopalakrishnan A, Shirey KA, Lai W, Vlk A, Mahurkar A, Nallar S, Hawkins LD, Ernst RK, Vogel SN. (2020) Dissociation of TRIF bias and adjuvanticity. Vaccine. 38:4298-4308. PMID: 32389496
- Ngaage LM, Elegbede A, Brao K, Chopra K, Gowda AU, Nam AJ, Ernst RK, Shirtliff ME, Harro J, Rasko YM. (2020) The efficacy of breast implant irrigant solutions: A comparative analysis utilizing an in vitro model. Plast Reconstr Surg. doi: 10.1097/PRS.0000000000007028. PMID: 32379180
- Cetuk H, Maramba J, Britt M, Scott AJ, Ernst RK, Mihailescu M, Cotten ML, Sukharev S. (2020) Differential Interactions of Piscidins with Phospholipids and Lipopolysaccharides at Membrane Interfaces. Langmuir. 36:5065-5077. doi: 10.1021/acs.langmuir.0c00017. Epub 2020 May 1.
- Heinrich F, Salyapongse A, Kumagai A, Dupuy FG, Shukla K, Penk A, Huster D, Ernst RK, Pavlova A, Gumbart JC, Deslouches B, Di YP, Tristram-Nagle S (2020) Synergistic Biophysical Techniques Reveal Structural Mechanisms of Engineered Cationic Antimicrobial Peptides in Lipid Model Membranes. Chemistry. doi: 10.1002/chem.202000212. PMID: 32166806
- Harberts E, Liang T, Yoon SH, Opene BN, McFarland MA, Goodlett DR, Ernst RK. (2020) Toll-like Receptor 4-Independent Effects of Lipopolysaccharide Identified Using Longitudinal Serum Proteomics. J Proteome Res. 19:1258-1266. doi: 10.1021/acs.jproteome.9b00765. PMID: 32037835
- Scott AJ, Chandler CE, Ellis SR, Heeren RMA, Ernst RK. (2019) Maintenance of Deep Lung Architecture and Automated Airway Segmentation for 3D Mass Spectrometry Imaging. Sci Rep. 9:20160. doi: 10.1038/s41598-019-56364-4. PMID: 31882724
- Crépin S, Ottosen EN, Chandler CE, Sintsova A, Ernst RK, Mobley HLT. (2019) The UDP-GalNAcA biosynthesis genes gna-gne2 are required to maintain cell envelope integrity and in vivo fitness in multi-drug resistant Acinetobacter baumannii. Mol Microbiol. 113:153-172. doi: 10.1111/mmi.14407. PMID: 31680352
- Sengyee S, Yoon SH, West TE, Ernst RK, Chantratita N. (2019) Lipopolysaccharides from Different Burkholderia Species with Different Lipid A Structures Induce Toll-Like Receptor 4 Activation and React with Melioidosis Patient Sera. Infect Immun. 87. pii: e00692-19. doi: 10.1128/IAI.00692-19. PMID: 31548320
- Barker W, Nemeth A, Brackett S, Basak A, Chandler CE, Jania L, Zuercher W, Melander RJ, Koller B, Ernst RK, Melander C. (2019) Repurposing Eukaryotic Kinase Inhibitors as Colistin Adjuvants in Gram-negative Bacteria. ACS Infect Dis. doi: 10.1021/acsinfecdis.9b00212. PMID: 31434474
- Krishnamoorthy G, Weeks JW, Zhang Z, Chandler C, Xue H, Schweizer HP, Ernst RK, Zgurskaya HI. (2019) Efflux pumps of Burkholderia thailandensis control the permeability barrier of the outer membrane. Antimicrob Agents Chemother. doi: 10.1128/AAC.00956-19. PMID: 31383661
- Ryu SY, Wendt GA, Chandler CE, Ernst RK, Goodlett DR. (2019) Model-Based Spectral Library Approach for Bacterial Identification via Membrane Glycolipids. Anal Chem. doi: 10.1021/acs.analchem.9b03340. PMID: 31369253
- Martin SE, Melander RJ, Brackett CM, Scott AJ, Chandler CE, Nguyen CM, Minrovic BM, Harrill SE, Ernst RK, Manoil C, Melander C. (2019) Small Molecule Potentiation of Gram-Positive Selective Antibiotics against Acinetobacter baumannii. ACS Infect Dis. 12:1223-1230. doi: 10.1021/acsinfecdis.9b00067. PMID: 31002491
- Kutschera A, Dawid C, Gisc N, Schmid C, Raasch L, Gerster T, Schäffer M, Smakowska-Luzan E, Belkhadir Y, Vlot AC, Chandler CE, Schellenberger R, Schwudke D, Ernst RK, Dorey S, Hückelhoven R, Hofmann T, and Ranf S (2019) Bacterial medium chain 3-hydroxy fatty acid metabolites trigger immunity in Arabidopsis plants. Science. Accepted for publication 4/2019
- Barker WT, Chandler CE, Melander RJ, Ernst RK, Melander C. (2019) Tryptamine derivatives disarm colistin resistance in polymyxin-resistant gram-negative bacteria. Bioorg Med Chem. pii: S0968-0896(19)30208-1. doi: 10.1016/j.bmc.2019.03.019. PMID:30898435
- Cooke AC, Nello AV, Ernst RK, Schertzer JW. (2019) Analysis of Pseudomonas aeruginosa biofilm membrane vesicles supports multiple mechanisms of biogenesis. PLoS One. 14(2):e0212275. doi: 10.1371/journal.pone.0212275. PMID:30763382
- Khan MM, Chattagul S, Tran BQ, Freiberg JA, Nita-Lazar A, Shirtliff ME, Sermswan RW, Ernst RK, Goodlett DR. (2019) Temporal proteomic profiling reveals changes that support Burkholderia biofilms. Pathog Dis. doi: 10.1093/femspd/ftz005. PMID:30759239
- Kumagai A, Dupuy FG, Arsov Z, Elhady Y, Moody D, Ernst RK, Deslouches B, Montelaro RC, Peter Di Y, Tristram-Nagle S. (2019) Elastic behavior of model membranes with antimicrobial peptides depends on lipid specificity and d-enantiomers. Soft Matter. 15(8):1860-1868. doi: 10.1039/c8sm02180e. PMID: 30702120
- Liang T, Leung LM, Opene B, Fondrie WE, Lee YI, Chandler CE, Yoon SH, Doi Y, Ernst RK, Goodlett DR. (2019) Rapid microbial identification and antibiotic resistance detection by mass spectrometric analysis of membrane lipids. Anal Chem. 2018 Dec 20. doi: 10.1021/acs.analchem.8b02611. PMID: 30571097
- Leung LM, McElheny CL, Gardner FM, Chandler CE, Bowler SL, Mettus RT, Spychala CN, Fowler EL, Opene BNA, Myers RA, Goodlett DR, Doi Y, Ernst RK. (2019) A Prospective Study of Acinetobacter baumannii Complex Isolates and Colistin Susceptibility Monitoring by Mass Spectrometry of Microbial Membrane Glycolipids. J Clin Microbiol. 57(3). pii: e01100-18. doi: 10.1128/JCM.01100-18. PMID: 30567747
- Chandler CE, Horspool AM, Hill PJ, Wozniak DJ, Schertzer JW, Rasko DA, Ernst RK. (2019) Genomic and Phenotypic Diversity among Ten Laboratory Isolates of Pseudomonas aeruginosa PAO1. J Bacteriology 201(5). pii: e00595-18. doi: 10.1128/JB.00595-18. PMID: 30530517
- Fondrie WE, Liang T, Oyler BL, Leung LM, Ernst RK, Strickland DK, Goodlett DR. (2018) Pathogen Identification Direct From Polymicrobial Specimens Using Membrane Glycolipids.Sci Rep. 8(1):15857. doi: 10.1038/s41598-018-33681-8. PMID: 30367087
- Mustapha MM, Li B, Pacey MP, Mettus RT, McElheny CL, Marshall CW, Ernst RK, Cooper VS, Doi Y. (2018) Phylogenomics of colistin-susceptible and resistant XDR Acinetobacter baumannii. J Antimicrob Chemother. Aug 14. doi: 10.1093/jac/dky290. PMID: 30124845
- Guillotte ML, Gillespie JJ, Chandler CE, Rahman MS, Ernst RK, Azad AF. (2018) Rickettsia Lipid A biosynthesis utilizes the late acyltransferase LpxJ for secondary fatty acid addition. J Bacteriol. Jul 16. pii: JB.00334-18. doi: 10.1128/JB.00334-18. PMID: 30012728
- Chandler CE, Harberts EM, Laemmermann T, Zeng Q, Opene BN, Germain RN, Jewell C, Scott AJ, Ernst RK. (2018) In vivo intradermal delivery of bacteria using microneedle arrays. Infect Immun. Jul 9. PMID: 29986891
- Khan MM, Ernst O, Sun J, Fraser IDC, Ernst RK, Goodlett DR, Nita-Lazar A. (2018) Mass Spectrometry-based Structural Analysis and Systems Immunoproteomics Strategies for Deciphering the Host Response to Endotoxin. J Mol Biol. S0022-2836(18):30661-2. PMID: 29949751
- Gregg KA, Harberts E, Gardner FM, Pelletier MR, Cayatte C, Yu L, McCarthy MP, Marshall JD, Ernst RK. (2018) A lipid A-based TLR4 mimetic effectively adjuvants a Yersinia pestis rF-V1 subunit vaccine in a murine challenge model. Vaccine. 36(28):4023-4031. PMID: 29861179
- Sengyee S, Yoon SH, Paksanont S, Yimthin T, Wuthiekanun V, Limmathurotsakul D, West TE, Ernst RK, Chantratita N. (2018) Comprehensive analysis of clinical Burkholderia pseudomallei isolates demonstrates conservation of unique lipid A structure and TLR4-dependent innate immune activation. PLoS Negl Trop Dis. 12(2):e0006287. PMID: 29474381
- Oyler BL, Khan MM, Smith DF, Harberts EM, Kilgour PDA, Ernst RK, Cross AS, Goodlett DR. (2018) Top down tandem mass spectrometric analysis of a chemically modified rough-type lipopolysaccharide vaccine candidate. JASMA. 29(6):1221-1229. doi: 10.1007/s13361-018-1897-y. PMID: 29464544
- Crawford MA, Fisher DJ, Leung LM, Lomonaco S, Lascols C, Cannatelli A, Giani T, Rossolini GM, Doi Y, Goodlett DR, Allard MW, Sharma SK, Khan E, Ernst RK, Hughes MA. (2017) CXC Chemokines Exhibit Bactericidal Activity against Multidrug-Resistant Gram-Negative Pathogens. MBio. 8(6) e01549-17. PMID: 29138303
- Scott AJ, Post JM, Lerner R, Ellis SR, Lieberman J, Shirey KA, Heeren RMA, Bindila L, Ernst RK. (2017) Host-based lipid inflammation drives pathogenesis in Francisella infection. Proc Natl Acad Sci. 114(47):12596-12601. PMID: 29109289
- Hajjar AM, Ernst RK, Yi J, Yam CS, Miller SI. (2017) Expression level of human TLR4 rather than sequence is the key determinant of LPS responsiveness. PLoS One. (10):e0186308. PMID: 29020088
- Zhang YF, Han K, Chandler CE, Tjaden B, Ernst RK, Lory S. (2017) Probing the sRNA regulatory landscape of P. aeruginosa: post-transcriptional control of determinants of pathogenicity and antibiotic susceptibility. Mol Microbiol. 106(6):919-937. PMID: 28976035.
- Leung LM, Cooper VS, Rasko DA, Guo Q, Pacey MP, McElheny CL, Mettus RT, Yoon SH, Goodlett DR, Ernst RK, Doi Y. (2017) Structural modification of LPS in colistin-resistant, KPC-producing Klebsiella pneumoniae. J Antimicrob Chemother. 72(11):3035-3042 PMID: 28961916.
- Barker WT, Martin SE, Chandler CE, Nguyen TV, Harris TL, Goodell C, Melander RJ, Doi Y, Ernst RK, Melander C. (2017) Small molecule adjuvants that suppress both chromosomal and mcr-1 encoded colistin-resistance and amplify colistin efficacy in polymyxin-susceptible bacteria. Bioorg Med Chem. S0968-0896. 31511-0. PMID: 28958847.
- Mi W, Li Y, Yoon SH, Ernst RK, Walz T, and Liao M. (2107) Structural basis of MsbA-mediated lipopolysaccharide transport. Nature. 549(7671):233-237. PMID: 28869968
- Chandler, CE, Ernst RK (2017) Bacterial lipids: powerful modifiers of the innate immune response. F1000Res.11388.1. eCollection PMID: 28868130
- Robert CB, Thomson M, Vercellone A, Gardner F, Ernst RK, Larrouy-Maumus G, Nigou J. (2017) Mass spectrometry analysis of intact Francisella bacteria identifies lipid A structure remodeling in response to acidic pH stress. Biochimie. S0300-9084(17)30205-5. PMID: 28807561
- Leung LM, Fondrie WE, Doi Y, Johnson JK, Strickland DK, Ernst RK, Goodlett DR (2017) Identification of the ESKAPE pathogens by mass spectrometric analysis of microbial membrane glycolipids. Sci Rep. 7(1):6403. PMID: 28743946
- Gregg KA, Harberts E, Gardner FM, Pelletier MR, Cayatte C, Yu L, McCarthy MP, Marshall JD, and Ernst RK. (2107) Rationally Designed TLR4 Ligands for Vaccine Adjuvant Discovery. MBio. 8(3). pii: e00492-17. PMID: 28487429
- Liu YY, Chandler CE, Leung LM, McElheny CL, Mettus RT, Shanks RM, Liu JH, Goodlett DR, Ernst RK, Doi Y. (2017) Structural Modification of Lipopolysaccharide Conferred by mcr-1 in Gram-Negative ESKAPE Pathogens. Antimicrob Agents Chemother. Apr 3. pii: AAC.00580-17. PMID: 28373195 * co-senior authors
- Shaw DK, Wang X, Brown LJ, Chávez AS, Reif KE, Smith AA, Scott AJ, McClure EE, Boradia VM, Hammond HL, Sundberg EJ, Snyder GA, Liu L, DePonte K, Villar M, Ueti MW, de la Fuente J, Ernst RK, Pal U, Fikrig E, Pedra JH. (2017) Infection-derived lipids elicit an immune deficiency circuit in arthropods. Nat Commun. 8:14401. PMID: 28195158
- Scott AJ, Oyler BL, Goodlett DR, Ernst RK. (2017) Lipid A structural modifications in extreme conditions and identification of unique modifying enzymes to define the Toll-like receptor 4 structure-activity relationship. Biochim Biophys Acta. pii: S1388-1981(17)30010-0. PMID: 28108356
- Richard K, Mann BJ, Qin A, Barry EM, Ernst RK, Vogel SN. (2017) Monophosphoryl Lipid A Enhances Efficacy of a Francisella tularensis LVS-Catanionic Nanoparticle Subunit Vaccine against F. tularensis Schu S4 Challenge by Augmenting both Humoral and Cellular Immunity. Clin Vaccine Immunol. 6;24(3). PMID: 28077440
- Jones CL, Singh SS, Alamneh Y, Casella LG, Ernst RK, Lesho EP, Waterman PE, Zurawski DV. (2017) In Vivo Fitness Adaptations of Colistin-Resistant Acinetobacter baumannii Isolates to Oxidative Stress. Antimicrob Agents Chemother. 61(3). pii: e00598-16. PMID: 27993849
- Kilgour DP, Hughes S, Kilgour SL, Mackay CL, Palmblad M, Tran BQ, Goo YA, Ernst RK, Clarke DJ, Goodlett DR. (2017) Autopiquer - a Robust and Reliable Peak Detection Algorithm for Mass Spectrometry.J Am Soc Mass Spectrom. 28(2):253-262. PMID: 27924495
- Corey BW, Thompson MG, Hittle LE, Jacobs AC, Asafo-Adjei EA, Huggins WM, Melander RJ, Melander C, Ernst RK, Zurawski DV. (2017) 1,2,4-Triazolidine-3-thiones Have Specific Activity against Acinetobacter baumannii among Common Nosocomial Pathogens. ACS Infect Dis. 3(1):62-71. PMID: 27764938
- Freiberg JA, Le Breton Y, Tran BQ, Scott AJ, Harro JM, Ernst RK, Goo YA, Mongodin EF, Goodlett DR, McIver KS, Shirtliff ME. (2016) Global Analysis and Comparison of the Transcriptomes and Proteomes of Group A Streptococcus Biofilms. mSystems. 2016 Dec 6;1(6). pii: e00149-16. eCollection Nov-Dec. PMID: 27933318
- SenGupta S, Hittle LE, Ernst RK, Uriarte SM, Mitchell TC. (2016) A Pseudomonas aeruginosa hepta-acylated lipid A variant associated with cystic fibrosis selectively activates human neutrophils. J Leukoc Biol. 100(5):1047-1059. PMID: 27538572
- Scott AJ, Flinders B, Cappell J, Liang T, Pelc RS, Tran B, Kilgour DP, Heeren RM, Goodlett DR, Ernst RK. (2016) Norharmane Matrix Enhances Detection of Endotoxin by MALDI-MS for Simultaneous Profiling of Pathogen, Host, and Vector Systems. Pathog Dis. pii: ftw097. PMID: 27650574
- Yoon SH, Liang T, Schneider T, Oyler BL, Chandler CE, Ernst RK, Yen GS, Huang Y, Nilsson E, Goodlett DR. (2016) Rapid Lipid A Structure Determination via Surface Acoustic Wave Nebulization and Hierarchical Tandem Mass Spectrometry Algorithm. Rapid Commun Mass Spectrom. PMID: 27582344
- Li Y, Yoon SH, Wang X, Ernst RK, Goodlett DR. (2016) Structural derivation of lipid A from Cronobacter sakazakii using tandem mass spectrometry. Rapid Commun Mass Spectrom. 30(20):2265-70. PMID: 27502448
- Brackett CM, Furlani RE, Anderson RG, Krishnamurthy A, Melander RJ, Moskowitz SM, Ernst RK, Melander C. (2016) Second Generation Modifiers of Colistin Resistance Show Enhanced Activity and Lower Inherent Toxicity. Tetrahedron. 23;72(25):3549-3553. PMID: 27429479
- Maldarelli GA, Piepenbrink KH, Scott AJ, Freiberg JA, Song Y, Achermann Y, Ernst RK, Shirtliff ME, Sundberg EJ, Donnenberg MS, von Rosenvinge EC. (2016) Type IV pili promote early biofilm formation by Clostridium difficile. Pathog Dis. 74(6). PMID: 27369898
- Stephens MD, Hubble VB, Ernst RK, van Hoek ML, Melander RJ, Cavanagh J, Melander C. (2016) Potentiation of Francisella Resistance to Conventional Antibiotics through Small Molecule Adjuvants. Medchemcomm. 2016 Jan 1;7(1):128-131. PMID:26877862
- Renzi F, Zähringer U, Chandler CE, Ernst RK, Cornelis GR, Ittig SJ. (2105)
Modification of the 1-Phosphate Group during Biosynthesis of Capnocytophaga canimorsus Lipid A. Infect Immun. 84(2):550-61. PMID: 26644381 - Varga JJ, Barbier M, Mulet X, Bielecki P, Bartell JA, Owings JP, Martinez-Ramos I, Hittle LE, Davis MR Jr, Damron FH, Liechti GW, Puchałka J, dos Santos VA, Ernst RK, Papin JA, Albertí S, Oliver A, Goldberg JB. (2015) Genotypic and phenotypic analyses of a Pseudomonas aeruginosa chronic bronchiectasis isolate reveal differences from cystic fibrosis and laboratory strains. BMC Genomics.16:883. PMID:26519161
- Chin CY, Gregg KA, Napier BA, Ernst RK, Weiss DS. A PmrB-Regulated Deacetylase Required for Lipid A Modification and Polymyxin Resistance in Acinetobacter baumannii. Antimicrob Agents Chemother. 59(12):7911-4. PMID: 26459891
- Hittle LE, Powell DA, Jones JW, Tofigh M, Goodlett DR, Moskowitz SM, Ernst RK. (2015) Site-specific activity of the acyltransferases HtrB1 and HtrB2 in Pseudomonas aeruginosa lipid A biosynthesis. Pathog Dis. pii: ftv053.
- Qureshi ZA, Hittle LE, O'Hara JA, Rivera JI, Syed A, Shields RK, Pasculle AW, Ernst RK, and Doi Y. (2105) Colistin-Resistant Acinetobacter baumannii: Beyond Carbapenem Resistance. Clin Infect Dis. 60:1295-1303. PMID: 25632010.
- Reinhart AA, Powell DA, Nguyen AT, O'Neill M, Djapgne L, Wilks A, Ernst RK, and Oglesby-Sherrouse AG. (2015) The prrF-encoded small regulatory RNAs are required for iron homeostasis and virulence of Pseudomonas aeruginosa. Infect Immun. 83:863-875. PMC4333466.
- Hittle LE, Jones JW, Hajjar AM, Ernst RK*, and Preston A*. (2015) Bordetella parapertussis PagP mediates the addition of two palmitates to the lipopolysaccharide lipid A. J Bacteriol. 197:572-580. PMCID: PMC4285993. * co-senior authors
- Knodler LA, Crowley SM, Sham HP, Yang H, Wrande M, Ma C, Ernst RK, Steele-Mortimer O, Celli J, Vallance BA. (2014) Noncanonical inflammasome activation of caspase-4/caspase-11 mediates epithelial defenses against enteric bacterial pathogens. Cell Host Microbe. 16:249-256. PMID: 25121752.
- Chirakul S, Bartpho T, Wongsurawat T, Taweechaisupapong S, Karoonutaisiri N, Talaat AM, Wongratanacheewin S, Ernst RK, Sermswan RW. (2014) Characterization of BPSS1521 (bprD), a regulator of Burkholderia pseudomallei virulence gene expression in the mouse model. PLoS One. 9:e104313. PMID: 25111708 * co-senior authors.
- Pilla DM, Hagar JA, Haldar AK, Mason AK, Degrandi D, Pfeffer K, Ernst RK, Yamamoto M, Miao EA, and Coers J. (2014) Guanylate binding proteins promote caspase-11-dependent pyroptosis in response to cytoplasmic LPS. PNAS. 22: 2046-6051. PMID: 24715728.
- Rolin O, Muse SJ, Safi C, Elahi S, Gerdts V, Hittle LE, Ernst RK, Harvill ET, and Preston A. (2014) Enzymatic Modification of Lipid A by ArnT Protects Bordetella bronchiseptica against Cationic Peptides and Is Required for Transmission. Infect Immun. 82:491-499. PMID: 24478065.
- Richard K, Mann BJ, Stocker L, Barry EM, Qin A, Cole LE, Hurley MT, Ernst RK, Michalek SM, Stein DC, Deshong P, and Vogel SN. (2014) Novel Catanionic Surfactant Vesicle Vaccines Protect against Francisella tularensis LVS and Confer Significant Partial Protection against F. tularensis Schu S4 Strain. Clin Vaccine Immunol. 21:212-226. PMID: 24351755.
- Chantratita N, Tandhavanant S, Myers ND, Seal S, Arayawichanont A, Kliangsa-Ad A, Hittle LE, Ernst RK, Emond MJ, Wurfel MM, Day NP, Peacock SJ, and West TE. (2014) Survey of innate immune responses to Burkholderia pseudomallei in human blood identifies a central role for lipopolysaccharide. PLoS One. 26:e81617. PMID: 24303060.
- Thaipisuttikul I,Hittle LE,Chandra R,Zangari D, Dixon CL, Garrett CA, Rasko DA, Dasgupta N, Moskowitz SM, Malmström L, Goodlett DR, Miller SI, Bishop RE, and Ernst RK (2013) A divergent Pseudomonas aeruginosa palmitoyltransferase essential for cystic fibrosis-specific lipid A. Mol Micro. 91:158-174. PMID: 24283944.
- Harris TL, Worthington RJ, Hittle LE, Zurawski DV, Ernst RK, and Melander C. (2013) Small Molecule Downregulation of PmrAB Reverses Lipid A Modification and Breaks Colistin Resistance. ACS Chem Biol. 17:122-127. PMID: 24131198.
- Li Y, Wang Z, Chen J, Ernst RK, and Wang X. (2013) Influence of lipid A acylation pattern on membrane permeability and innate immune stimulation. Mar Drugs. 11:3197-208. PMID: 24065161.
- Hagar JA, Powell DA, Aachout Y, Ernst RK, and Miao EA. (2013) Cytoplasmic LPS activates caspase-11: implications in TLR4-independent endotoxic shock. Science. 341:1250-1253. PMID: 24031018.
- Scott AJ, Jones JW, Orschell CM, MacVittie TJ, Kane, MA, and Ernst RK. (2013) Mass Spectrometry Imaging Enriches Biomarker Discovery Approaches with Candidate Mapping. Health Physics Journal. 106:106-109. PMID: 24276555.
- Jones JW, Scott AJ, Tudor G, Jackson IL, Vujaskovic Z, MacVittie TJ, Ernst RK, and Kane, MA. (2013) Identification and Quantitation of Biomarkers for Radiation-Induced Injury via Mass Spectrometry. Health Physics Journal. 106: 24276554.
- Pelletier MR, Casella LG, Jones JW, Adams MD, Zurawski DV, Hazlett KR, Doi Y, Ernst RK. (2013) Unique Structural Modifications are Present in the LPS from Colistin-Resistant Strains of Acinetobacter baumannii. Antimicrob Agents Chemother. 57:4831-4840. PMID: 23877686.
- Shirey KA, Lai W, Scott AJ, Lipsky M, Mistry P, Pletneva LM, Karp KL, McAlees J, Gioannini TL, Weiss J, Chen WH, Ernst RK, Rossignol DR, Gusovsky F, Blanco JC, Vogel SN (2013) The TLR4 Antagonist, Eritoran, Protects Mice from Lethal Influenza Infection. Nature. 497:498-502. PMID: 23636320.
- Nchoutmboube JA, Viktorova EG, Scott AJ, Ford LA, Pei Z, Watkins PA, Ernst RK, and Belov GA. (2013) Increased long chain acyl-CoA synthetase activity and fatty acid import is linked to membrane synthesis for development of picornavirus replication organelles. PLOS Pathogens. 9:e1003401. PMID: 23762027.
- Rebeil R, Jarrett CO, Driver JD, Ernst RK, Oyston PC, Hinnebusch BJ. (2013) Induction of the Yersinia pestis PhoP-PhoQ regulatory system in the flea and its role in producing a transmissible infection. J Bact. 2013195:1920-30. PMID: 23435973.
- O'Hara JA, Ambe LA, Casella LG, Townsend BM, Pelletier MR, Ernst RK, Shanks RM, Doi Y. (2013) Activities of vancomycin-containing regimens against colistin-resistant Acinetobacter baumannii clinical strains. Antimicrob Agents Chemother. 57:2103-8. PMID: 23422916
- Powell DA, Li Y, Ernst RK. (2102) Turning up Francisella pathogenesis: The LPS thermostat. Virulence. 3: 594-595. PMID: 2315428.
- Morin N, Santiago AE, Ernst RK, Guillot SJ, Nataro JP. (2012) Characterization of the AggR Regulon in Enteroaggregative E. coli. Infect Immun. 81:122-132. PMID: 23090962.
- Hajjar AM, Ernst RK, Fortuno ES, Brasfield AS, Yam CS, Newlon LA, Kollmann TR, Miller SI, and Wilson CB (2012) Humanized TLR4/MD-2 Mice Reveal LPS Recognition Differentially Impacts Susceptibility to Yersinia pestis and Salmonella enterica. PLOS Pathogens. 8(10):e1002963. PMID: 2307143.
- Yoon SH, Huang Y, Edgar JS, Ting YS, Heron SR, Kao Y, Li Y, Masselon CD, Ernst RK, Goodlett DR. (2012) Surface Acoustic Wave Nebulization Facilitating Lipid Mass Spectrometric Analysis. Anal Chem. 84:6530-6537. PMID: 22742654.
- Li, Y, Powell, DA, Shaffer SA, Rasko DA, Pelletier M, Leszyk JD, Scott AJ, Masoudi A, Goodlett DA, Wang X, Raetz CRH, and Ernst RK. (2012) LPS remodeling is an evolved survival strategy for bacteria. PNAS. 109:8716-8721. PMID: 22586119.
- Kanistanon D, Powell DA, Hajjar AM, Pelletier MR, Cohen IE, Way SS, Skerrett SJ, Wang X, Raetz CRH, and Ernst RK. (2012) Role of Francisella Lipid A Phosphate Modification in Virulence and Long-Term Protective Immune Responses. Infect Immun. 80(3): 943-851. PMID: 22215738.
- Klein KA, Fukuto HS, Pelletier M, Romanov G, Grabenstein JP, Palmer LE, Ernst RK, and Bliska JB. (2011) A transposon-site hybridization screen identifies galU and wecBC as important for survival of Yersinia pestis in murine macrophages. J Bact. 194:653-662. PMID: 22139502.
- Galen JE, Simon R, and Ernst RK. (2011) Salmonella expressing detoxified lipopolysaccharide is immunogenic and protective both as an attenuated vaccine and for delivery of foreign antigens. Expert Rev Vaccines. 10:1679-1682. PMID: 22085171.
- Scott A, Weldon S, Buchanan P, Schock B, Ernst RK, McAuley DF, Tunney MM, Irwin CR, Elborn SJ, and Taggart C. (2011) Evaluation of the Ability of LL-37 to Neutralise LPS in vitro and ex vivo. PLoS ONE. 6:e26525. PMID: 22025598.
- 122.Simon R, Tennant SM, Wang JY, Schmidlein PJ, Lees A, Ernst RK, Pasetti MF, Galen JE, Levine MM. (2011) Salmonella Enteritidis Core-O Polysaccharide (COPS) conjugated to H:g,m flagellin as a candidate vaccine for protection against invasive infection with Salmonella Enteritidis. Infect Immun. 79:4240-4249. PMID: 21807909.
- 123.Ting YS, Shaffer SA, Jones JW, Ng WV, Ernst RK, Goodlett DR. (2011) Automated lipid A structure assignment from hierarchical tandem mass spectrometry data. J Am Soc Mass Spectrom. 22:856-866. PMID: 21472520.
- 124.Damron FH, Davis MR Jr, Withers TR, Ernst RK, Goldberg JB, Yu G, Yu HD. (2011) Vanadate and triclosan synergistically induce alginate production by Pseudomonas aeruginosa strain PAO1. Mol Microbiol. 81:554-570. PMID: 21631603.
- MacArthur I, Jones JW, Goodlett DR, Ernst RK* and Preston A* (2011) The role of pagL and lpxO in Bordetella bronchiseptica lipid A biosynthesis. J Bact. 193:4726-4735. PMID: 21764941* co-senior authors.
- Li Y, Wang X, and Ernst RK. (2011) A Rapid One-Step Method for the Characterization of Membrane Lipid Remodeling in Francisella using MALDI-TOF/TOF Mass Spectrometry. Rapid Communications in Mass Spectrometry. 25:2641-2648. PMID: 23657959.
- Jassem AN, Zlosnik JE, Henry DA, Hancock RE, Ernst RK, Speert DP. (2011) In vitro susceptibility of Burkholderia vietnamiensis to aminoglycosides. Antimicrob Agents Chemother 55:2256-2264. PMID: 21321142.
- Lai XH, Shirley RL, Crosa L, Kanistanon D, Tempel R, Ernst RK, Gallagher LA, Manoil C, Heffron F. (2011) Mutations of Francisella novicida that alter the mechanism of its phagocytosis by murine macrophages. PLoS One. 5:e11857. PMID: 20686600.
- Moskowitz SM and Ernst RK (2010) The role of Pseudomonas lipopolysaccharide in cystic fibrosis airway infection. Subcell Biochem. 53:241-53. PMID: 20593270.
- Jones JW, Cohen IE, Tureček F, Goodlett DR, and Ernst RK (2010) Comprehensive Structure Characterization of Lipid A Extracted From Yersinia pestis for Determination of its Phosphorylation Configuration. J Am Soc Mass Spectrom. 21:785-799. PMID: 20185334.
- Carlson RW and Gunn GS (2010) Francisella tularensis blue–gray phase variation involves structural modifications of lipopolysaccharide O-antigen, core, and lipid A and affects intramacrophage survival and vaccine efficacy. Frontiers in Microbiology. 1:129. PMID: 21687776.
- Pilonieta MC, Erickson KD, Ernst RK, and Detweiler CS. (2009) A Protein Important for Antimicrobial Peptide Resistance, YdeI/OmdA, is in the Periplasm and Interacts with OmpD/NmpC. J Bact. 191:7243-7252. PMID: 19767429. Times Cited – 18
- Coats SR, Jones JW, Do CT, Braham PH, Bainbridge BW, To TT, Goodlett DR, Ernst RK, and Darveau RP. (2009) Human Toll-like receptor 4 responses to P. gingivalis are regulated by lipid A 1- and 4'-phosphatase activities. Cell Microbiol. 11:1587-1599. PMID: 19552698
- Berezow AB, Ernst RK, Coats SR, Braham PH, Karimi-Naser LM, and Darveau RP. (2009) The structurally similar, penta-acylated lipopolysaccharides of Porphyromonas gingivalis and Bacteroides elicit strikingly different innate immune responses. Microb. Pathog. 47:68-77. PMID: 19460428.
- Buchanan PJ, Ernst RK, Elborn JS, and Schock B. (2009) Role of CFTR, Pseudomonas aeruginosa and Toll-like receptors in cystic fibrosis lung inflammation. Biochem Soc Trans. 37(Pt 4):863-867. PMID: 19614608.
- Kalhorn TF, Kiavand A, Cohen IE, Nelson AK, and Ernst RK. (2008) A sensitive liquid chromatography/mass spectrometry-based assay for quantitation of amino-containing moieties in lipid A. Rapid Communications in Mass Spectrometry. 23:433-442. PMID: 19130491.
- Jones JW, Shaffer SA, Ernst RK, Goodlett DR, and Turecek F. (2008) Determination of Pyrophosphorylated Forms of Lipid A in Gram-Negative Bacteria Using a Multi-Varied Mass Spectrometric Approach. PNAS.105:12742-12747. PMID: 18753624.
- West TE, Ernst RK, Jansson-Hutson MJ, and Skerrett SJ. (2008) Activation of Toll-like receptors by Burkholderia pseudomallei. BMC Immunol. 8:46. PMID: 18691413.
- Bainbridge BW, Karimi-Naser L, Reife R, Blethen F, Ernst RK, and Darveau RP. (2008) Acyl chain specificity of the acyltransferases lpxA and lpxD and substrate availability contribute to lipid A fatty acid heterogeneity in Porphyromonas gingivalis. J. Bact. 190:4549-4558. PMID: 18456814.
- Miao EA, Ernst RK, Dors M, Mao DP, and Aderem A. (2008) Pseudomonas aeruginosa activates caspase 1 though Ipaf. PNAS. 105:2562-2567. PMID: 18256184.
- Kanistanon D, Hajjar AM, Pelletier MR, Gallagher LA, Kalhorn T, Shaffer SA, Goodlett DR, Rohmer L, Brittnacher M, Skerrett SJ, and Ernst RK (2008) A Francisella Mutant in Lipid A Carbohydrate Modification Elicits Protective Immunity. PLoS Pathogens. 4:e24. PMID: 18266468
- Ernst RK, Moskowitz SM, Emerson JC, Kraig GM, Adams KN, Harvey MD, Ramsey BW, Speert DP, Burns JL and Miller SI. (2007) Unique lipid A modifications in Pseudomonas aeruginosa isolated from the airways of patients with cystic fibrosis. J. Infect. Diseases. 196:1088-1092. PMID: 17763333.
- Rohmer L, Fong C, Abmayr S, Wasnick M, Freeman TJ, Radey M, Guina T, Svensson K, Hayden HS, Jacobs M, Gallagher LA, Manoil C, Ernst RK, Drees B, Buckley D, Haugen E, Bovee D, Zhou Y, Chang J, Levy R, Lim R, Gillett W, Guenthener D, Kang A, Shaffer SA, Taylor G, Chen J, Gallis B, D'Argenio DA, Forsman M, Olson MV, Goodlett DR, Kaul R, Miller SI, Brittnacher MJ. (2007) Comparison of Francisella tularensis genomes reveals evolutionary events associated with the emergence of human-pathogenic strains. Genome Biol. 8:R102. PMID: 17550600.
- Mohapatra NP, Soni S, Bell BL, Warren R, Ernst RK, Muszynski A, Carlson R and Gunn JS. (2007) Identification of an orphan response regulator required for Francisella virulence and transcription of pathogenicity island genes. Infect. Immun. 75:3305-3314. PMID: 17452468.
- D’Argenio DA, Hoffman LR, Deziel E, Smith EE, Hayden H, Klausen M, Ernst RK, Burns JL, Ramsey BW, Speert DP, Olson MV and Miller SI. (2007). Growth phenotypes of Pseudomonas aeruginosa lasR mutants adapted to the airways of cystic fibrosis patients. Mol Microbiol. 64:512-533. PMID: 17493132.
- Murray SR, Ernst RK, Bermudes D, Miller SI and Low KB. (2007) PmrAC confers pmrHFIJKL-dependent EGTA and polymyxin resistance to msbB Salmonella by decorating lipid A with phosphoethanolamine. J. Bact. 189:5161-5169. PMID: 17449614.
- Shaffer SA, Harvey MD, Goodlett DR, and Ernst RK. (2007) Structural Heterogeneity and Environmentally Regulated Remodeling of Francisella tularensis subspecies novicida Lipid A Characterized by Tandem Mass Spectrometry. J Am Soc Mass Spectrom. 18:1080-1092. PMID: 17446084.
- Waters VJ, Gomez MI, Soong G, Amin S, Ernst RK, and Prince A. (2007) Immunostimulatory properties of the emerging pathogen Stenotrophomonas maltophilia. Infect Immun. 75:1698-1703. PMID: 17220304.
- Haagensen JAJ, Klausen M, Ernst RK, Miller SI, Folkesson A, Tolker-Nielsen T and Molin S. (2007) Differentiation and Distribution of Colistin/SDS Tolerant Cells in Pseudomonas aeruginosa Biofilms. J Bact. 189:28-37. PMID: 17041046.
- Hajjar AM, Harvey MD, Shaffer SA, Goodlett DR, Sjostedt A, Edebro H, Forsman M, Pelletier M, Wilson CB, Miller SI, Skerrett SJ and Ernst RK. (2006) Lack of in vitro and in vivo recognition of Francisella subspecies LPS by Toll-like receptors. Infect Immun. 74:6730-6738. PMID: 16982824.
- Ernst RK, Adams, KN, Moskowitz, SM, Kraig, GM, Kawasaki, K, Stead CM, Trent MS, and Miller SI. (2006) The Pseudomonas aeruginosa Lipid A Deacylase: Selection for Expression and Loss Within the Cystic Fibrosis Airway. J Bact. 188:191-201. PMID: 16352835.
- Rebeil R, Ernst RK, Jarrett CO, Adams KN, Miller SI, and Hinnebusch BJ. (2006) Characterization of Late Acyltransferase Genes of Yersinia pestis and their Role in Temperature-dependent Lipid A Variation. J Bact. 188:1381-1388. PMID: 16452420.
- Kawasaki K, Ernst RK, and Miller SI. (2005) Purification and characterization of deacylated and/or palmitoylated lipid A species unique to Salmonella enterica serovar Typhimurium. J Endotoxin Research. 11:57-61. PMID: 15826380.
- Kawasaki K, Ernst RK, and Miller SI. (2005) Inhibition of Salmonella typhimurium outer membrane deacylation by aminoarabinose membrane modification. J Bact. 187:2448-2457. PMID: 15774888.
- Tanabe H, Ayabe T, Bainbridge B, Guina T, Ernst RK, Darveau RP, Miller MI, and Ouellette AJ. (2005) Mouse Paneth Cell Secretory Responses to Cell Surface Glycolipids of Virulent and Attenuated Pathogenic Bacteria. Infect Immun. 73:2312-2320. PMID: 15784576.
- Bylund J, Burgess L-A, Cescutti P, Ernst RK, and Speert DP. (2005) Exopolysaccharides from Burkholderia cenocepacia inhibit neutrophil chemotaxis and scavenge reactive oxygen species. J Biol Chem. 81:2526-2532. PMID: 16316987.
- Beckmann C, Britmacher M, Ernst RK, Hamblett N, Miller SI, and Burns J. (2005) The use of phage display to identify potential Pseudomonas aeruginosa gene products relevant to early cystic fibrosis airway infections. Infect Immun. 73:444-452. PMID: 15618183.
- Lindgren H, Golovliov I, Baranov V, Ernst RK, Telepnev M, and Sjostedt A. (2004) Factors affecting the escape of Francisella tularensis from the phagolysosome. J Med Microbiol. 53:953-958. PMID: 15358816.
- Rebeil R*, Ernst RK*, Gowen BB, Miller SI, and Hinnebusch BJ. (2004) Variation in lipid A structure in the pathogenic yersiniae. Mol Micro. 52:1363-1373. PMID: 15165239 * Co-first authors
- Skerrett SJ, Liggitt HD, Hajjar AM, Ernst RK, Miller SI, and Wilson CB. (2004) Respiratory Epithelial Cells Regulate Lung Inflammation in Response to Inhaled Endotoxin. Am J Physiol Lung Cell Mol Physiol. 287:L143-152. PMID: 15047567.
- Kawasaki K, Ernst RK, and Miller SI. (2004) 3-O-deacylation of lipid A by PagL, a PhoP/PhoQ-regulated deacylase of Salmonella typhimurium, modulates signaling through toll-like receptor 4. J Biol Chem. 279:20044-20048. PMID: 15014080.
- Kawasaki K, Ernst RK, and Miller SI. (2004) Deacylation and palmitoylation of lipid A by Salmonellae outer membrane enzymes modulate host signaling through Toll-like receptor 4. J Endotoxin Research 10: 439-444. PMID: 15588428.
- Moskowitz SM, Ernst RK, and Miller SI. (2004) PmrAB, a Two-Component Regulatory System of Pseudomonas aeruginosa that Modulates Resistance to Cationic Antimicrobial Peptides and Addition of Aminoarabinose to Lipid A. J Bact. 186:575-579. PMID: 14702327.
- Ernst RK, Hajjar AM, Tsai JH, Moskowitz SM, Wilson CB, and Miller SI. (2003) Pseudomonas aeruginosa Lipid A Diversity and its Recognition by Toll-like Receptor 4. J Endotoxin Research 9:395-400. PMID: 14733728.
- Ernst RK, D’Argenio DA, Ichikawa JK, Bangera MG, Selgrade S, Burns JL, Hiatt P, McCoy K, Brittnacher M, Kas A, Spencer DH, Olson MV, Ramsey BW, Lory S, and Miller SI. (2003) Genome mosaicism is conserved but not unique in Pseudomonas aeruginosa isolates from the airways of young children with cystic fibrosis. Environmental Microbiology 5:1341-1349. PMID: 14641578.
- Guina T, Wu M, Miller SI, Purvine SO, Yi EC, Eng J, Goodlett DR, Aebersold R, Ernst RK, and Lee KA. (2003) Proteomic analysis of Pseudomonas aeruginosa grown under magnesium limitation. J Am Soc Mass Spectrom. 7:742-751. PMID: 12837596.
- Plesner A, Greenbaum CJ, Guar LK, Ernst RK, and Lernmark A. (2002) Macrophages from high risk HLA-DQB1*0201/0302 type 1 diabetes mellitus patients are hypersensitivity to lipopolysaccharide stimulation. Scand J Immunol. 56:522-529. PMID: 12410803.
- Brodsky IE, Ernst RK, Miller SI, and Falkow S. (2002) Mig-14 (pmrO) is involved in Salmonella resistance to antimicrobial peptides. 184:3203-3213. PMID: 1229036.
- Hajjar A*, Ernst RK*, Wilson C, and Miller SI. (2002) Human Toll-like receptor 4 recognizes host-specific LPS modifications. Nature Immunology 3:354-359. PMID: 11912497 * Co-first authors.
- Perez-Melgosa M, Ochs HD, Linsley PS, Laman JD, van Meurs M, Flavell RA, Ernst RK, Miller SI, and Wilson CB. (2001) Carrier-mediated enhancement of cognate T cell help: the basis for enhanced immunogenicity of meningococcal outer membrane protein polysaccharide conjugate vaccine. Eur J Immunol. 31:2373-2381. PMID: 11500820.
- Gunn JS, Ryan SS, Van Velkinburgh JC, Ernst RK, and Miller SI. (2000) Genetic and functional analysis of a PmrA-PmrB-regulated locus necessary for lipopolysaccharide modification, antimicrobial peptide resistance, and oral virulence of Salmonella enterica serovar typhimurium. Infect Immun. 68:6139-6146. PMID: 11035717.
- Yethon JA, Gunn JS, Ernst RK, Miller SI, Laroche L, Malo D, and Whitfield C.
(2000) Salmonella enterica serovar typhimurium waaP mutants show increased susceptibility to polymyxin and loss of virulence in vivo. Infect Immun. 68:4485-4491. PMID: 10899846. - Gunn JS, Ernst RK, McCoy AJ, and Miller SI. (2000) Constitutive mutations of the Salmonella enterica serovar typhimurium transcriptional virulence regulator phoP. Infect Immun. 68: 3758-3762. PMID: 10816543.
- Ernst RK, Yi EC, Guo L, Lim KB, Burns JL, Hackett M, and Miller SI. (1999) Specific lipopolysaccharide found in cystic fibrosis airway Pseudomonas aeruginosa. Science 286:1561-1565. PMID: 10567263.
- Pasquinelli, AE, Ernst RK, Lund E, Grimm C, Zapp M, Rekosh R, Hammarskjold M-L and Dahlberg JE. (1997) The constitutive transport element (CTE) of Mason-Pfizer Monkey Virus (MPMV) accesses a cellular mRNA export pathway and binds specific proteins. EMBO J 16: 7500-7510. PMID: 9405378.
- Ernst RK, Bray M, Rekosh D and Hammarskjold M-L. (1997) Secondary structure and mutational analysis of the Mason-Pfizer Monkey Virus RNA constitutive transport element. RNA 3: 210-222. PMID: 9042947.
- Ernst RK, Bray M, Rekosh D and Hammarskjold M-L. (1997) A structured retroviral RNA element that mediates nucleocytoplasmic export of intron-containing RNA. Cell Biol 17: 135-144. PMID: 8972193.
- Ernst RK, Dombroski DM and Merrick JM. (1990) Anaerobiosis, type 1 fimbriae and growth phase are factors that affect invasion of HEp-2 cells by Salmonella typhimurium. Infect Immun 58: 2014-2016. PMID: 1971262.
- Abud RL, Lindquist BL, Ernst RK, Merrick JM, Lebanthale and Lee PC. (1989) Concanavalin A promotes adherence of Salmonella typhimurium. Proc Soc Exp Biol Med 192: 81-86. PMID: 2678127.